Vectric Aspire - The complete software solution for CNC Routing,
Autodesk Fusion 360 - Integrated CAD, CAM, and CAE featuring collaborative editing and cloud-based computation.
PyCAM - PyCAM is a toolpath generator for 3-axis CNC machining.
MeshCAM - MeshCAM is the fastest way to generate gcode
SprutCAM - SprutCAM all-in-one software for CNC machines programming
Mach3 - Mach3 is very popular among the Hobby CNC community.