wxWidgets - wxWidgets: Cross-Platform GUI Library
PyQt - Riverbank | Software | PyQt | What is PyQt?
GTK - GTK+ is a multi-platform toolkit for creating graphical user interfaces.
Kivy - Open source Python framework for rapid development of applications that make use of innovative user interfaces, such as multi-touch apps. Installation on WindowsInstallation on Windows. Installation; What are wheels .
Electron - Build cross platform desktop apps with web technologies
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.