Resprite
Aseprite
Pixelorama
Piskel
Pixen
LibreSprite
Grafx2
Pixilart
SimpleX
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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Pixelorama - Free and open source sprite editor and animator, ideal for pixel art.
Piskel - Piskel is a website where designers online create sprites or pixel art.
Pixen - Pixen is a professional pixel art editor designed for working with low-resolution raster art, such as those 8-bit sprites found in old-school video games.
LibreSprite - Free and open source program to create animated sprites.
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.