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Pyforms - Pyforms is a Python 3 framework to develop applications capable of executing in 3 diferent environments, Desktop GUI, Terminal and Web.
Unity - The multiplatform game creation tools for everyone.
wxPython - wxPython is a GUI toolkit for the Python programming language.
Godot Engine - Feature-packed 2D and 3D open source game engine.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Blender - Blender is the open source, cross platform suite of tools for 3D creation.