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Dear PyGui - Dear PyGui is a simple to use (but powerful) Python GUI framework. Dear PyGui provides a wrapping of Dear ImGui which simulates a traditional retained mode GUI (as opposed to Dear ImGui's immediate mode paradigm).
Unity - The multiplatform game creation tools for everyone.
PySimpleGUI - A simple to use GUI that can create custom GUIs
Godot Engine - Feature-packed 2D and 3D open source game engine.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Blender - Blender is the open source, cross platform suite of tools for 3D creation.