PyQt - Riverbank | Software | PyQt | What is PyQt?
Unity - The multiplatform game creation tools for everyone.
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
Godot Engine - Feature-packed 2D and 3D open source game engine.
Dear PyGui - Dear PyGui is a simple to use (but powerful) Python GUI framework. Dear PyGui provides a wrapping of Dear ImGui which simulates a traditional retained mode GUI (as opposed to Dear ImGui's immediate mode paradigm).
Blender - Blender is the open source, cross platform suite of tools for 3D creation.