Star Trek Online - Star Trek Online (STO) is a free to play MMORPG that takes place inside the Star Trek world.
Sins Of A Solar Empire - Sins of a Solar Empire is an Adventure, Strategy, Real-time-strategy, Science-fiction, Exploration, Aliens, Single and Multiplayer Space Simulation developed by Ironclad Games and published by Stardock.
EVE Online - Player-created empires, player-driven markets, and endless ways to embark on your personal sci-fi adventure.
Endless Space - Endless Space is an Amazing, Strategy, Science-fiction, Turn-based, Space, Futuristic, Exploration, Co-op, Single and Multiplayer Space Simulation created and published by Amplitude Studios.
X3: Terran Conflict - X3: Terran Conflict is part of the X number of video games.
X Rebirth - X Rebirth is an Action-Adventure, Sci-fi, Open World, Sandbox, Trading, Strategy, Space and Single player Simulation created and developed by Egosoft.