Derby.js - MVC framework making it easy to write realtime, collaborative applications that run in both Node.
Koa.js - Next generation web framework for node.js
Ruby on Rails - Ruby on Rails is an open source full-stack web application framework for the Ruby programming...
Sails.js - Realtime MVC Framework for Node.js
AngularJS - AngularJS lets you extend HTML vocabulary for your application. The resulting environment is extraordinarily expressive, readable, and quick to develop.
ExpressJS - Sinatra inspired web development framework for node.js -- insanely fast, flexible, and simple