Vulkan - Vulkan is a new generation graphics and compute API that provides high-efficiency, cross-platform access to modern GPUs used in a wide variety of devices from PCs and consoles to mobile phones and embedded platforms.
PyQt - Riverbank | Software | PyQt | What is PyQt?
raylib - Cross-platform, open-source game development library in C.
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
Allegro - Allegro 4 and Allegro 5 are cross-platform, libraries mainly aimed at video game and multimedia...
MD Python Designer - A drag and drop GUI Designer that uses a combination of Tkinter and its own code.