raylib - Cross-platform, open-source game development library in C.
PyQt - Riverbank | Software | PyQt | What is PyQt?
SFML - SFML provides a simple interface to the various components of your PC, to ease the development of games and multimedia applications. It is composed of five modules: system, window, graphics, audio and network.
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
SDL - Simple DirectMedia Layer is a cross-platform multimedia library designed to provide low level...
MD Python Designer - A drag and drop GUI Designer that uses a combination of Tkinter and its own code.