Unity - The multiplatform game creation tools for everyone.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Godot Engine - Feature-packed 2D and 3D open source game engine.
PySimpleGUI - A simple to use GUI that can create custom GUIs
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
wxWidgets - wxWidgets: Cross-Platform GUI Library