Sprite Fusion - Design your game with Sprite Fusion, the ultimate free online tilemap editor. Design 2D games with ease, direclty export to Unity Tilemap and Godot Scenes. Ideal for retro games!
Spine - Spine is 2D animation software designed specifically for software and game development.
Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Synfig Studio - Just another WordPress site
LibreSprite - Free and open source program to create animated sprites.
Live2D Cubism - Live2D is the world's first drawing technology to enable 3D rendering of 2D images.