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Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
wxWidgets - wxWidgets: Cross-Platform GUI Library
wxPython - wxPython is a GUI toolkit for the Python programming language.
GTK - GTK+ is a multi-platform toolkit for creating graphical user interfaces.
PyGUI - A simple API that enables developers to create user interfaces with native elements for Python applications.
Electron - Build cross platform desktop apps with web technologies