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Texture Studio - Texture Studio is all you need to produce professional quality textures for use in games and tiled...
Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Pixen - Pixen is a professional pixel art editor designed for working with low-resolution raster art, such as those 8-bit sprites found in old-school video games.
Pixelorama - Free and open source sprite editor and animator, ideal for pixel art.
TextureLab - Free, Cross-Platform, GPU-Accelerated Procedural Texture Generator.
Piskel - Piskel is a website where designers online create sprites or pixel art.