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Texture Studio - Texture Studio is all you need to produce professional quality textures for use in games and tiled...
Material Maker - Cross-platform, procedural texture generation tool.
Pixen - Pixen is a professional pixel art editor designed for working with low-resolution raster art, such as those 8-bit sprites found in old-school video games.
Substance Designer - Substance Designer is a node-based non-destructive application for material authoring.
Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Filter Forge - On the surface, Filter Forge is just a Photoshop plugin, a pack of filters that generate textures...