Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
AnyLogic - AnyLogic has changed simulation modeling and expanded its application into complex business environments. The unmatched flexibility of multimethod modeling allows users to capture the complexity of virtually any system, at any level of detail.
RawTherapee - RawTherapee is a free RAW converter and digital photo processing software.
FlexSim - Simulation software to model, simulate, predict, and visualize systems in manufacturing, material handling, healthcare, warehousing, mining, etc.
MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
Simio - Facility design simulation & production scheduling