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Pygame - Pygame is a set of Python modules designed for writing games.
wxWidgets - wxWidgets: Cross-Platform GUI Library
Unigine - Unigine Engine is a proprietary cross-platform middleware, developed by Unigine Corp.
Electron - Build cross platform desktop apps with web technologies
libtwo - All-purpose c++ app prototyping library, focused towards live graphical apps and games
GTK - GTK+ is a multi-platform toolkit for creating graphical user interfaces.