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Pygame - Pygame is a set of Python modules designed for writing games.
OpenToonz - OpenToonz is an animation program that is a free software version of Toonz, the animation software...
Unigine - Unigine Engine is a proprietary cross-platform middleware, developed by Unigine Corp.
Synfig Studio - Just another WordPress site
libtwo - All-purpose c++ app prototyping library, focused towards live graphical apps and games
Adobe Animate - Adobe Animate is a Flash, vector animation software.