perf - Perf is a simple app monitoring solution paired with meaningful alerts.
EasyHook - The reinvention of Windows API Hooking
strace - Trace system calls and signals. A diagnostic, debugging and instructional userspace utility.
Microsoft Research Detours - Detours is a software package for re-routing Win32 APIs underneath applications.
DTrace - DTrace is a performance analysis and troubleshooting tool for Solaris, Mac OS X and FreeBSD.
madCodeHook - "madCodeHook" offers everything you need to hook code (mostly APIs).