DarkOrbit - DarkOrbit provides a space focused MMO that allows players take control over their own spacecraft.
Elite Dangerous - Elite Dangerous is a 2015 Trading, Action, Sci-fi, Exploration, Open World and Space Simulation by Frontier Developments.
SpaceX ISS Docking Simulator - Pilot the SpaceX Dragon 2 vehicle to the ISS!
X3: Terran Conflict - X3: Terran Conflict is part of the X number of video games.
Out There - Out There is a space exploration game blending resource management and gamebook with no combat.
EVE Online - Player-created empires, player-driven markets, and endless ways to embark on your personal sci-fi adventure.