Unity - The multiplatform game creation tools for everyone.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Godot Engine - Feature-packed 2D and 3D open source game engine.
Tkinter - Tkinter is a Python wrapper for Tcl/Tk that offers classes to create various graphical user interfaces.
Unreal Engine - Unreal Engine 4 is a suite of integrated tools for game developers to design and build games, simulations, and visualizations.
MD Python Designer - A drag and drop GUI Designer that uses a combination of Tkinter and its own code.