Gwibber - Gwibber is an open source microblogging client for GNOME developed with Python and GTK.
Twidere - Tired of seeing ads and promotions in your timeline, being disrupted by tweets from bots and people...
TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
Hyperspace Mastodon client - Hyperspace offers a clean, fast and responsive client for the Mastodon social network
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Pinafore - An alternative web client for Mastodon, focused on speed and simplicity.