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Gwibber - Gwibber is an open source microblogging client for GNOME developed with Python and GTK.
Whalebird - Whalebird is a Mastodon client for desktop application.
TweetDeck - TweetDeck is your personal browser for staying in touch with what’s happening now.
Twidere - Tired of seeing ads and promotions in your timeline, being disrupted by tweets from bots and people...
Tweetbot - Sync your timeline across your iPhone, iPad, and Mac. Mute tweets by user, hashtag, tweet source, or keywords (including regex). 3rd Party support for image, video, read later, and timeline sync services.
Pinafore - An alternative web client for Mastodon, focused on speed and simplicity.