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Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
jasymca - Jasymca is an interactive System for solving math problems.
RStudio - RStudio™ is a new integrated development environment (IDE) for R.
GNU Octave - GNU Octave is a programming language for scientific computing.
Orange - Machine learning for novice and experts.