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Spine - Spine is 2D animation software designed specifically for software and game development.
Godot Engine - Feature-packed 2D and 3D open source game engine.
Synfig Studio - Just another WordPress site
MonoGame - MonoGame is an open source implementation of the Microsoft XNA 4 Framework.
Animation Paper - Animation Paper is a software package for doing 2D animation.
BYOND - BYOND is the premier community for making and playing online multiplayer games.