Loopback by RogueAmoeba - Get all the power of a high-end studio mixing board, right inside your Mac!
Sails.js - Realtime MVC Framework for Node.js
Nest.js - A progressive Node.js framework for building efficient, reliable and scalable server-side applications.
ExpressJS - Sinatra inspired web development framework for node.js -- insanely fast, flexible, and simple
hapi.js - Server Framework for Node.js
Meteor - Meteor is a set of new technologies for building top-quality web apps in a fraction of the time.