Infuse - Media player and media server with subtitles and wide codec support.
Home-Assistant.io - Home Assistant is an open-source home automation platform running on Python 3.
Universal Media Server - Universal Media Server allows you to host your entire library of video, music, and pictures, and broadcast them conveniently to a wide variety of different devices.
ioBroker - flexible and modular application for the IoT and Smarthome
Kodi - Kodi is an award winning free and open source media player that got its start on the Xbox console.
openHAB - "empowering the smart home" - vendor and technology agnostic open source home automation