Mesen - Mesen is a NES/Famicom emulator and NSF player.
Nestopia - A portable and cycle-accurate NES emulator written in C++
puNES - PuNES is a high accuracy NES emulator.
Jnes - Jnes is a NES emulator for win32 platforms that uses DirectX for its hardware interface.
My Nes - My Nes is a portable open source NES/FAMICOM emulator written in C#.
NESBox - Nesbox Emulator is a multiplatform emulator of video consoles.