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Unity - The multiplatform game creation tools for everyone.
KoolMoves - Inexpensive animation software that combines ease-of-use with powerful effects for creating high quality Html5, GIF, AVI, and SWF animations and mobile apps
Godot Engine - Feature-packed 2D and 3D open source game engine.
Sencha Animator - I just learned about the halt to production and development of Sencha Animator.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Adobe Animate - Adobe Animate is a Flash, vector animation software.