Unity - The multiplatform game creation tools for everyone.
Krita - Krita is a professional FREE and open source painting program. It is made by artists that want to seaffordable art tools for everyone. Concept art. texture and matte painters, illustrations and comics.
Godot Engine - Feature-packed 2D and 3D open source game engine.
Clip Studio Paint - The artist's software for drawing and painting.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
MyPaint - MyPaint is a fast, distraction-free, and easy painting tool for digital artists.