Campaign Cartographer - Campaign Cartographer is the leading map making software for games (RPGs, miniatures and wargaming).
PyMapper - Drag and drop tile based mapping program.
Tabletop RPG Map editor 2 - RPG Map II is a “tabletop RPG” oriented map maker, created with the “keep it clean & simple” philosophy in mind.
Dungeon Tile Mapper - Dungeon Tile Mapper is a web based tile mapping tool that includes many official D&D tile sets.
Dungeon Scrawl - A dungeon scrawling tool by ProbableTrain
Fractal Mapper - With Fractal Mapper, creating worlds has never been so easy!