MySims Kingdom - MySims Kingdom is based upon The Sims series but provides special and extremely different gameplay to the original series making it definitely worth your consideration.
Species - Species is an Action, Role-playing, Real-time Strategy, Single and Multiplayer Life-Simulation.
Movie Star Planet - Movie Star Planet is an Online Virtual World, MMO, and RPG Simulation by MovieStarPlanet.
Populous - Populous is an Action, Role-playing, Real-time Strategy, Single and Multiplayer god game developed by Bullfrog and published by Electronic Arts.
OurWorld - OurWorld is an Action, Great Online Virtual World, Social Interaction, MMO, and RPG Simulation by Flow Play.
Darwinia - Darwinia is an Action Role-playing, Real-time Strategy, Isometric and Single-player video game developed and published by Introversion Software.