Pixi.js - Fast lightweight 2D library that works across all devices
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Anime.js - Lightweight JavaScript animation library
Cinema 4D - Cinema 4D is a 3D modeling, animation, motion graphics and rendering application.
Glottologist - JavaScript translation framework
ZBrush - ZBrush is a digital sculpting and painting software solution.