MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
BioWin - BioWin
Autodesk Fusion 360 - Integrated CAD, CAM, and CAE featuring collaborative editing and cloud-based computation.
STOAT - STOAT - a dynamic sewage treatment works modelling package
AnyLogic - AnyLogic has changed simulation modeling and expanded its application into complex business environments. The unmatched flexibility of multimethod modeling allows users to capture the complexity of virtually any system, at any level of detail.
Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.