MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
BioWin - BioWin
GNU Octave - GNU Octave is a programming language for scientific computing.
AQUASIM - In order to support environmental scientists in finding an «adequate» model of the system...
Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
DWSIM - DWSIM is an open-source CAPE-OPEN compliant chemical process simulator for Windows and Linux.