OfflineList - A widely-used, multi-platform ROM manager.
LaunchBox - LaunchBox is a portable, box-art-based games database and launcher for DOSBox, emulators, arcade cabinets, and PC Games. Download it free!
RomCenter - Universal ROM Manager. List, examines and repairs all your ROMS. Missing roms ?
HyperSpin - HyperSpin is an animated arcade frontend for Windows for use on Home Arcade Machines.
EmuControlCenter - Manage roms and emulators for more than 190 gaming platforms with one tool
GameEx - GameEx is considered to be the most powerful and feature rich front-end for MAME, GameBase, Daphne, PC Games and all command line based game emulators, along with being a complete Home Theatre PC solution.