I use Bottles for some lightweight software I have for game development, like Pyxel Edit. No complaints so far— it works fine. Source: about 1 year ago

This is an original graphical representation of both the size (number of unique stages) and scope (amount of objectives to complete) of the mainline Super Mario games. It was created by quite adept in a program called Pyxel Edit using 8 colors, over the course of a few slow work days. These 18 games are what Nintendo considers to be mainline Super Mario games, minus the two Mario Maker games and Super Mario Run.... Source: over 1 year ago

I use PyxelEdit. It's built especially for making tileart/tilesets and it's only $9 smackaroos! Https://pyxeledit.com/. Source: over 1 year ago

Https://pyxeledit.com/ (more tile set development). Source: over 2 years ago

I use a program called pyxel edit, which is made specifically for pixel art. I'd highly recommend it, it's a very simple but does this kind of art style extremely well and only costs $10 usd. Source: over 2 years ago

That said, my kid, above all else, had the most fun with paintz.app (website), just creating pictures. He's moved onto brush.ninja now (at 7) and is doing simple gif animations. Source: over 1 year ago

I wasn't sure if that was allowed. The site is brush.ninja, I shall update the original post to show this too. Source: about 2 years ago

Https://brush.ninja/ is fast/nice if you just want to do quick stick figure type animated gifs. Start by drawing something simple in the current frame, then down at the bottom, use the "duplicate" to make the next frame and add some changes. - Source: Hacker News / about 2 years ago

I can suggest brush.ninja for online (2D) animations or OpenToonz/FlipaClip for downloadable software animations, along with Blender for 3D animations (all of these are free to download and use). Source: over 2 years ago