Jira may be extremely sluggish and require a large amount of memory on the client side.
Helix ALM - Helix ALM is the single, integrated application that lets you centralize and manage requirements, test cases, issues, and other development artifacts and their relationships.
Trello - Infinitely flexible. Incredibly easy to use. Great mobile apps. It's free. Trello keeps track of everything, from the big picture to the minute details.
codeBeamer ALM - Integrated application lifecycle management (ALM) platform
Asana - Asana project management is an effort to re-imagine how we work together, through modern productivity software. Fast and versatile, Asana helps individuals and groups get more done.
Visual Studio Team Services - Visual Studio Team Services (VSTS) provides unlimited Git hosting, cloud build for CI, agile planning and continuous delivery.
Wrike - Wrike is a flexible, scalable, and easy-to-use collaborative work management software that helps high-performance teams organize and accomplish their work. Try it now.
We have been using PTC Integrity since 2002 when it was call MKS Integrity Suite. If you do not have it setup correctly it will fail for you. It has gotten so bad that we our dumping PTC entirely and switching to Jira. PTC support is lacking, often very slow even when we are paying extra for higher level of support.
I recommend - PTC Integrity.