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Wine - Open Source Software for running Windows applications on other operating systems.
Porting Kit - Install Windows Games in Mac OS X natively and easily and for free with Wineskin technology
CodeWeavers CrossOver - Don't buy a Windows license, don't reboot and don't use a Virtual Machine. Try a free trial of CrossOver to run your Windows software on Mac, Linux and Chrome OS.
Vineyard - Windows programs on Linux, easily
PlayOnLinux - PlayOnLinux will allow you to play your favorite games on Linux easily
Lutris - Lutris is an open source gaming platform for GNU/Linux.