MATLAB - A high-level language and interactive environment for numerical computation, visualization, and programming
Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
GNU Octave - GNU Octave is a programming language for scientific computing.
FlexSim - Simulation software to model, simulate, predict, and visualize systems in manufacturing, material handling, healthcare, warehousing, mining, etc.
Enterprise Architect - Enterprise Architect - UML Design Tools and UML CASE tools for software development | Sparx Systems
Maxima - Maxima is a fairly complete computer algebra system written in Lisp with an emphasis on symbolic computation.