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RetroArch - RetroArch is a frontend for emulators, game engines and media players.
Wine - Open Source Software for running Windows applications on other operating systems.
Mupen64Plus - N64 emulator and plugins for Linux, Mac OSX, FreeBSD, and Windows
CodeWeavers CrossOver - Don't buy a Windows license, don't reboot and don't use a Virtual Machine. Try a free trial of CrossOver to run your Windows software on Mac, Linux and Chrome OS.
1964 - 1964 is a Nintendo 64 emulator for Microsoft Windows, written in C and released as free software.
WineBottler - WineBottler is an App to manage and wrap your Windows apps into convenient OS X apps.