Gnumeric - Gnumeric
IGOR Pro - Technical graphing and data analysis for Macintosh and Windows.
Microsoft Office Excel - Microsoft Office Excel is a commercial spreadsheet application.
SciDaVis - SciDAVis is a free application for Scientific Data Analysis and Visualization.
LibreOffice - Calc - LibreOffice Calc is the spreadsheet program you've always needed. A fork of OpenOffice.
LabPlot - LabPlot is a KDE-application for interactive graphing and analysis of scientific data.