Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Cinema 4D - Cinema 4D is a 3D modeling, animation, motion graphics and rendering application.
Piskel - Piskel is a website where designers online create sprites or pixel art.
ZBrush - ZBrush is a digital sculpting and painting software solution.