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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Synfig Studio - Just another WordPress site
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Duik - Comprehensive animation and rigging toolset for Adobe After Effects
LibreSprite - Free and open source program to create animated sprites.
Limber for After Effects - IK system for After Effects using shape layers as limbs for character animation