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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Pixel Studio - The Pixel Art Is Always Fun
LibreSprite - Free and open source program to create animated sprites.
Pixel Art to CSS - Draw and animate pixel art, export the results to CSS
Piskel - Piskel is a website where designers online create sprites or pixel art.