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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
GIMP - GIMP is a multiplatform photo manipulation tool.
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Krita - Krita is a professional FREE and open source painting program. It is made by artists that want to seaffordable art tools for everyone. Concept art. texture and matte painters, illustrations and comics.
LibreSprite - Free and open source program to create animated sprites.
MyPaint - MyPaint is a fast, distraction-free, and easy painting tool for digital artists.