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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Lottie by Airbnb - Easily add high-quality animation to any native app
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Spirit - The animation tool for the web.
LibreSprite - Free and open source program to create animated sprites.
Haiku Animator - Create powerful animations for any app or website