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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
OpenToonz - OpenToonz is an animation program that is a free software version of Toonz, the animation software...
Grafx2 - GrafX2 is a bitmap paint program inspired by the Amiga programs Deluxe Paint and Brilliance.
Synfig Studio - Just another WordPress site
LibreSprite - Free and open source program to create animated sprites.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.