Game Character Hub - helper program for game design (RPG Maker XP/VX and more)
Universal LPC Spritesheet Character Generator - Powerful, animated character generator for creating 2D spritesheets
001 Game Creator - Make Games. No Coding.
Blender - Blender is the open source, cross platform suite of tools for 3D creation.
Sculptris - Sculptris: Enter a world of digital art without barriers.
Misfit Model 3D - Misfit Model 3D is a 3D model editor that basically operates with triangle-based models.