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Aseprite - Aseprite is an art program dedicated to the creation of pixel art.
Pixel Art Studio - A purpose-built drawing tool for pixel artists
Pixilart - A drawing app for delightfully retro pixel art
Pixel Studio - The Pixel Art Is Always Fun
Piskel - Piskel is a website where designers online create sprites or pixel art.
piCSSel-art - Draw pixel art with CSS!